of topiramate and gabapentin on neuropathic pain induced in rats by sciatic
Dr. Hossam El
sisi and Dr. Ibrahim Awwad
College of Pharmacy
This is to certify that this graduation
project report entitled “Effect
of topiramate and gabapentin on neuropathic pain
induced in rats by sciatic nerve ligation” is submitted to the College of Pharmacy, Qassim University in partial
fulfilment of the requirements for the degree of Doctor of Pharmacy (Pharm.D)
by Abdullatif Obaidallah alharbi under the supervision of Dr.Hossam Elsisi &
Dr.Ibrahim Awwad. I hereby confirm that the work submitted in this project is
my own. I have not violated the college’s policy on plagiarism.
4List of Figures and Tables
4List of Abbreviations
5Introduction and Review of literature 6Aims of the Study 6 Materials and Method 7 Results 10
I would like to thank my supervisors
Dr.Hossam Elsisi and Dr.Ibrahim Awwad for their tremendous help, support and
time that they had spent with me in the lab and outside lab from the first day
of graduation project. Also, I would like to thank Dr.Sultan Sajid for his help
in lab. Last but not least, I would like to thank my friend Waleed Alharbi for
his help and support.
Figures and Tables
(GBP) Gabapentin ,(TPM)
Topiramate , (TPM) Thiopental,(CBZ) carbamazepine.
To study the effect of
topiramate and gabapentin on neuropathic pain induced in rats by sciatic nerve
To compare the effect of topiramate and gabapentin on neuropathic pain
induced in rats by sciatic nerve ligation
The hypothesis of this study is that topiramate and gabapentin is effective to treatment
Study design: Experimental study
Equipments : Analgesia
Drugs: Gabapentin ,Topiramate ,Thiopental.
There is significance effect (p