Effect 7 Results 10 10. Discussion 13 11.

Effect
of topiramate and gabapentin on neuropathic pain induced in rats by sciatic
nerve ligation

(Final
report)

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Submitted by:

    Abdullatif
Obaidallah alharbi

ID:321102889

 

Supervision  by

Dr. Hossam El
sisi and Dr. Ibrahim Awwad

College of Pharmacy

Qassim University

DEC 2017

CERTIFICATE

This is to certify that this graduation
project report entitled “Effect
of topiramate and gabapentin on neuropathic pain
induced in rats by sciatic nerve ligation” is submitted to the College of Pharmacy, Qassim University in partial
fulfilment of the requirements for the degree of Doctor of Pharmacy (Pharm.D)
by Abdullatif Obaidallah alharbi under the supervision of Dr.Hossam Elsisi &
Dr.Ibrahim Awwad. I hereby confirm that the work submitted in this project is
my own. I have not violated the college’s policy on plagiarism.

 

Dr.Hossam
Elsisi

Signature:

 

Dr.Ibrahim Awwad

Signature:

 

Abdullatif Alharbi

Signature:

 

Table
of contents

                                                                                                Page
Number

Acknowledgment                                                               
   4List of Figures and Tables                                                 
   4List of Abbreviations                                                         
   4Abstract                                                                                            5Keywords                                                                              
5Introduction and Review of literature                                  6Aims of the Study                                                                            6        Materials and Method                                                           7        Results                                                                                   10      

10.                       
Discussion                                                                             
13

11.                       
 conclusion                                                               
             13

12.                       
 References                                                                                               13          

 

 

 

 

 

 

Acknowledgment:

I would like to thank my supervisors
Dr.Hossam Elsisi and Dr.Ibrahim Awwad for their tremendous help, support and
time that they had spent with me in the lab and outside lab from the first day
of graduation project. Also, I would like to thank Dr.Sultan Sajid for his help
in lab. Last but not least, I would like to thank my friend Waleed Alharbi for
his help and support.

 

Figures and Tables

                                                                                          Page Number

Figure  1                                                                        
         8         

Figure 
2                                                                                 10

Table 1                                                                                     
 11

Table 2                                                                                      
11

Table 3                                                                                      
12

Figure 3                                                            
                     12

 

 

Abbreviations :

 (GBP) Gabapentin ,(TPM)
Topiramate , (TPM) Thiopental,(CBZ) carbamazepine.

 

 

Abstract:

Objectives:

To study the effect of
topiramate and gabapentin on neuropathic pain induced in rats by sciatic nerve
ligation.

To compare the effect of topiramate and gabapentin on neuropathic pain
induced in rats by sciatic nerve ligation

Hypothesis:

The hypothesis of this study is that topiramate and gabapentin is effective to treatment
neuropathic pain.

Methodology:

§    
Study design: Experimental study

§    
Sampling: rats

§    
Equipments  : Analgesia
Meter

§    
Drugs: Gabapentin ,Topiramate ,Thiopental.

Results :

There is significance effect (p